Can we stop antibiotic resistance from ruining promising drugs before they reach patients?

AI Summary

Researchers from HUN-REN BRC Szeged and HCEMM propose a five-step framework to identify antibiotic-resistance risks early in drug development. The approach aims to help refine promising antibiotic candidates and reduce the chance that resistance undermines them before they reach patients.

What if we could predict early in drug development which antibiotics bacteria are most likely to become resistant to? In a review published in Nature Reviews Microbiology, researchers from the HUN-REN Biological Research Centre, Szeged (HUN-REN BRC Szeged) and the Hungarian Centre of Excellence for Molecular Medicine (HCEMM) in Szeged propose a five-step decision-making framework that could help identify resistance risks early, refine promising drug candidates and prevent costly failures.