Researchers identify key pathway that drives T-cell exhaustion in cancer immunotherapy

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UCLA researchers used a CRISPR screen to identify a molecular pathway that contributes to exhaustion in cancer-fighting T cells. The finding could help explain why immune cells lose their ability to control tumors and may inform future improvements to cancer immunotherapy.

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.